Detailed view for EgrG_000454700

Basic information

TDR Targets ID: 587722
Echinococcus granulosus, Microtubule-associated serine/threonine-protein kinase
Source Database / ID:  GeneDB

pI: 8.0419 | Length (AA): 2075 | MW (Da): 223343 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00595   PDZ domain (Also known as DHR or GLGF)
PF08926   Domain of unknown function (DUF1908)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0000287   magnesium ion binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
822 931 2m9x (A) 1 112 42.00 0 1 0.500312 -0.16
833 931 1v9v (A) 8 108 39.00 0.00000000031 1 0.596811 -0.99
943 1419 3nyn (A) 67 555 18.00 0 0.82 0.29178 0.84
969 1338 4ejn (A) 24 438 33.00 0 1 0.218613 0.71
992 1342 2f2u (B) 27 396 33.00 0 1 0.336457 0.24
1023 1359 4lqq (A) 316 744 34.00 0 0.99 0.21171 1.61
1042 1496 4yzb (A) 10 473 21.00 0 1 0.230177 0.46
1053 1339 3tku (A) 70 371 33.00 0 1 0.337613 -0.28
1057 1340 4nw6 (A) 66 359 41.00 0 1 0.411967 0.15
1162 1206 4xh0 (A) 107 154 36.00 0.28 0.85 0.354787 0.32
1660 1767 1uf1 (A) 4 100 35.00 0 1 0.259948 0.39
1679 1772 2kqf (A) 3 96 45.00 0 1 0.548601 -0.32
1681 1774 4n6x (A) 12 97 33.00 0.009 1 0.393601 -0.87
1715 1767 2rcz (A) 207 260 26.00 0 0.72 0.265442 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127530)

Species Accession Gene Product
Arabidopsis thaliana AT1G48490   putative protein kinase
Arabidopsis thaliana AT5G62310   putative serine/threonine protein kinase IRE
Arabidopsis thaliana AT1G45160   protein kinase
Arabidopsis thaliana AT3G17850   protein kinase family protein
Brugia malayi Bm1_57280   KIAA0303
Caenorhabditis elegans CELE_C10C6.1   Protein KIN-4, isoform B
Dictyostelium discoideum DDB_G0272282   MAST family protein kinase
Drosophila melanogaster Dmel_CG6498   CG6498 gene product from transcript CG6498-RB
Echinococcus granulosus EgrG_000454700   Microtubule-associated serine/threonine-protein kinase
Entamoeba histolytica EHI_006750   protein kinase, putative
Entamoeba histolytica EHI_193290   hypothetical protein
Echinococcus multilocularis EmuJ_000712200   serine:threonine protein kinase greatwall
Echinococcus multilocularis EmuJ_000454700   microtubule associated serine:threonine protein
Homo sapiens ENSG00000105613   microtubule associated serine/threonine kinase 1
Homo sapiens ENSG00000069020   microtubule associated serine/threonine kinase family member 4
Homo sapiens ENSG00000099308   microtubule associated serine/threonine kinase 3
Homo sapiens ENSG00000086015   microtubule associated serine/threonine kinase 2
Loa Loa (eye worm) LOAG_07481   AGC/MAST/MAST protein kinase
Mus musculus ENSMUSG00000031833   microtubule associated serine/threonine kinase 3
Mus musculus ENSMUSG00000053693   microtubule associated serine/threonine kinase 1
Mus musculus ENSMUSG00000003810   microtubule associated serine/threonine kinase 2
Mus musculus ENSMUSG00000034751   microtubule associated serine/threonine kinase family member 4
Oryza sativa 4333889   Os03g0711800
Oryza sativa 4352821   Os12g0621500
Schistosoma mansoni Smp_174820   serine/threonine protein kinase
Schmidtea mediterranea mk4.000282.03  
Schmidtea mediterranea mk4.000085.04  
Schmidtea mediterranea mk4.002603.00  
Schmidtea mediterranea mk4.002041.01  
Trichomonas vaginalis TVAG_479710   AGC family protein kinase
Trichomonas vaginalis TVAG_312180   AGC family protein kinase
Trichomonas vaginalis TVAG_347430   AGC family protein kinase
Trichomonas vaginalis TVAG_030400   AGC family protein kinase
Trichomonas vaginalis TVAG_587270   serine/threonine-protein kinase, putative
Trichomonas vaginalis TVAG_011160   AGC family protein kinase
Trichomonas vaginalis TVAG_470980   AGC family protein kinase
Trichomonas vaginalis TVAG_359020   AGC family protein kinase
Trichomonas vaginalis TVAG_346740   AGC family protein kinase
Trichomonas vaginalis TVAG_047880   AGC family protein kinase
Trichomonas vaginalis TVAG_405930   AGC family protein kinase
Trichomonas vaginalis TVAG_504520   AGC family protein kinase
Trichomonas vaginalis TVAG_597230   AGC family protein kinase
Trichomonas vaginalis TVAG_020880   AGC family protein kinase

Essentiality

EgrG_000454700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C10C6.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens microtubule associated serine/threonine kinase 1 Compounds References
Homo sapiens microtubule associated serine/threonine kinase 3 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 33.9% 307 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.9% 249 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.5% 310 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 26.4% 296 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 34.5% 307 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 33.5% 307 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0125 0.3882 0
0.0011 1 1
0.0063 1 1
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0098 0.3242 0.2282
0.0039 0.9485 0.9402
0.0066 0.3101 0.7874
0.0004 0.5 0.5
0.0064 0.3377 0.5563
0.0088 0.4477 0.4477
0.0022 0.5 0.5
0.0091 1 1
0.0039 0.5 0.5
0.0061 0.6883 0.6883
0.0008 0.5 0.5
0.0018 0.5 0.5
0.0016 0.5 0.5
0.0093 0.8828 0
0.0012 0.5 0.5
0.0092 1 1
0.0032 0.5 0.5
0.0059 1 1
0.0042 0.5 0.5
0.0062 0.6935 0.733
0.0059 1 1
0.0081 0.5 0.5
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0069 0.3067 0.3067
0.0059 1 1
0.0033 0.5 0.5
0.0063 0.7244 0
0.0039 0.5 0.5
0.0125 0.3882 0
0.0026 0.5 0.5
0.0067 0.5 0.5
0.0033 1 1
0.0023 0.5 0.5
0.0056 1 1
0.0029 0.5 0.5
0.0037 1 1
0.0007 0.5 0.5
0.0081 1 1
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0027 1 1
0.0003 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier EgrG_000454700 (Echinococcus granulosus), Microtubule-associated serine/threonine-protein kinase
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